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Optinose Announces Closing of Initial Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares of Common Stock

Yardley, PA, Oct. 17, 2017 – OptiNose, Inc. (NASDAQ:OPTN), a specialty pharmaceutical company focused on the development and commercialization of products for patients treated by ear, nose and throat (ENT) and allergy specialists, today announced the closing of its initial public offering of 8,625,000 shares of common stock at a public offering price of $16.00 per share, which includes an additional 1,125,000 shares of common stock issued upon the exercise in full by the underwriters of their option to purchase additional shares. The aggregate gross proceeds to Optinose from the offering were approximately $138 million, before deducting underwriting discounts and commissions and estimated offering expenses payable by Optinose. All of the shares were offered and sold by Optinose. The shares of common stock began trading on the NASDAQ Global Select Market on October 13, 2017 under the ticker symbol “OPTN.”

Jefferies and Piper Jaffray acted as the lead joint book-running managers of the offering. BMO Capital Markets and RBC Capital Markets also acted as joint book-running managers for the offering.

A registration statement relating to the securities sold in the offering was declared effective by the Securities and Exchange Commission on October 12, 2017. This offering was made only by means of a prospectus. Copies of the final prospectus relating to this offering were filed with the SEC and may be obtained from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, or by telephone at 877-821-7388 or by email at [email protected]; Piper Jaffray & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, or by telephone at 800-747-3924 or by email at [email protected]; BMO Capital Markets Corp., Attention: Equity Syndicate Department, 3 Times Square, 25th Floor, New York, NY 10036, or by telephone at 800-414-3627 or by email at [email protected]; and RBC Capital Markets LLC, Attention: Equity Syndicate, 200 Vesey Street, 8th Floor, New York, NY 10281-8098 or by telephone at 877-822-4089 or by email at [email protected].